Brain-Stimulation Technology Research

TMS / Imaging Integration

Imaging of brain activity during TMS or electrical stimulation is central to understanding and optimizing research and clinical stimulation paradigms. We are currently completing the installation of state-of-the-art systems that allow functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) to be carried out simultaneously with TMS. We are also developing technology for synchronizing TMS application to various aspects of endogenous brain activity sensed by EEG. There is evidence that the intrinsic state of the brain affects the outcome of TMS. Thus, coupling TMS to cerebral dynamics in real time can offer further enhancement and control over the modulation of brain activity for therapeutic purposes. EEG-TMS synchronization work is funded by a New York State Psychiatric Institute (NYSPI) Frontier Fund grant to Dr. Peterchev and Dr. Lisanby's NYSTAR award. FMRI-TMS integration is supported by a DRAPA grant with co-PI Dr. Lisanby.

Related Publications

• Radman, T., Datta, A., Peterchev, A. V. (2007). In vitro modulation of endogenous rhythms by AC electric fields: Syncing with clinical brain stimulation. J Physiol 584 (2): 369-370.