Brain-Stimulation Technology Research

Induced Field Mapping in MST and ECT

Electrode placement and electrical dosage significantly impact the therapeutic efficacy and side effect profile of electroconvulsive therapy (ECT). Magnetic seizure therapy (MST) has been investigated as a more focal alternative to ECT with potentially reduced side effects. We are carrying out research to map the induced current density distribution and its relationship to seizure expression in ECT and MST. Such information could be useful in interpreting clinical results with existing forms of ECT and MST, and in optimizing the stimulation parameters.

Related Publications

• Radman, T., Datta, A., Peterchev, A. V. (2007). In vitro modulation of endogenous rhythms by AC electric fields: Syncing with clinical brain stimulation. J Physiol 584 (2): 369-370.
• Peterchev, A. V., Berman, R., Luber, B., Schroeder, C. E., Truesdale, M. D., Kaplan, D. M., Brodsky, J., and Lisanby, S. H. (2007). Relationship between electric field and ictal power induced by electroconvulsive shock (ECS) and magnetic seizure therapy (MST) in nonhuman primates. Am Coll Neuropsychopharmacol Ann Mtg Abstr (CD-ROM).
• Lisanby, S. H., Scalia, J., Cycowicz, Y., Peterchev, A. V., Spellman, T., Dwork, A., Underwood, M., Terrace, H., and Arango, V. (2008). Anatomical, physiological and cognitive effects of rTMS-induced seizures in primates: Implications for magnetic seizure therapy and rTMS safety guidelines. Abstr 3rd International Conference on TMS and tDCS (accepted).